Opening Remarks
Koutaro Yokote (Chiba University, Chiba, Japan)

Plenary Lecture 1
Chair: Koutaro Yokote (Chiba University, Chiba, Japan)

The Werner Syndrome: Past, Present & Future
George M. Martin (University of Washington, Seattle, USA)

Session 1 Clinical Features and Genetics of Werner Syndrome
Chairs: Raymond J. Monnat (University of Washington, Seattle, USA)
Seijiro Mori (Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan)

Lessons from Werner syndrome: A biased view from a rheumatologist

Genomic clues to Werner syndrome disease pathogenesis and cancer risk

International Registry of Werner Syndrome: Search for progeroid syndrome mutations and mechanisms
Junko Oshima (University of Washington, Seattle, USA)

Session 2 Bloom Syndrome and Stem Cell Aging in Skin
Chairs: Nathan A. Ellis (University of Arizona, Tucson, USA)

NSMCE2 is required for the generation of sister chromatid exchanges at collapsed replication forks

Altered Nucleolar Trafficking of the Blm Helicase in the Mouse Reduces Size, Increases Tumor Susceptibility and Genome Instability, and Facilitates Aging

Stem cells orchestrate hair follicle aging program
Emi Nishimura (Tokyo Medical and Dental University, Tokyo, Japan)

Patients and Families Session
Chairs:Joanna L. Groden (The Ohio State University, Columbus, USA)
Yoshiro Maezawa (Chiba University, Chiba, Japan)

From Werner syndrome patient group

From Cockayne syndrome patient group

From Rothmund-Thomson syndrome patient group

Poster Session

Welcome Reception at Hotel Okura

Plenary Lecture 2
Chair: Hironori Nakagami (Osaka University, Osaka, Japan)

Werner syndrome: mechanisms and intervention
Vilhelm A. Bohr (National Institute of Aging, Bethesda, USA)

Session 3 Travel Award Presentations and Mini Presentations of Poster Presenters
Chairs:Junko Oshima (University of Washington, Seattle, USA)
Minoru Takemoto (International University of Health and Welfare, Narita, Japan)

Travel Awardees and All the Poster Presenters

Luncheon Seminar (Sponsored by Novo nordisk Pharma Limited)
Chair: Shigeki Kuzuhara (Suzuka University of Medical Science, Suzuka, Japan)

Werner Syndrome Research in Japan: For the Patient and Aging Science
Koutaro Yokote? (Chiba University, Chiba, Japan)

Session 4 Rothmund-Thomson Syndrome, Mitochondrial Dysfunction and Aging
Chairs:Lisa L. Wang (Texas Children’s Hospital, Baylor College of Medicine, Houston, USA)
Hideo Kaneko (Nagara Medical Center, Gifu, Japan)

Update on Clinical Studies of Rothmund-Thomson Syndrome and RECQL4 Disorders
Lisa L. Wang (Texas Children’s Hospital, Baylor College of Medicine, Houston, USA)

Role of RECQL4 in genome maintenance
Deborah L. Croteau (National Institute on Aging, Bethesda, USA)

Mitol dependent ubiquitylation of RECQL4 prevents its function as an accessory factor for mitochondrial DNA replication
Sagar Sengupta (National Institute of Immunology, New Delhi, India)

Roles of mitochondrial ubiquitin ligase MITOL in mitochondrial dynamics and aging-related diseases
Shigeru Yanagi (Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan)

Plenary Lecture 3

Genome-Wide promotome and enhancerome analysis based on CAGE technology and its application to the identification of cancer biomarkers
Yoshihide Hayashizaki (Riken, Wako, Japan)

Session 5 Aging related Diseases and Hutchinson Gilford Progeria Syndrome (Co-sponsored by Daiichi Sankyo Company, Limited)
Chairs:Vilhelm A. Bohr (National Institute of Aging, Bethesda, USA)
Kenji Ihara (Oita University, Oita, Japan)

Mitotic death of cancer cells by gene silencing of RECQ helicases: a preferential sensitivity of ovarian cancer cells to RECQL1-siRNA

Role of Akt in skeletal muscle in anti-aging
Kohjiro Ueki
(Tokyo University and National Center for Global Health and Medicine, Tokyo, Japan)

Immunometabolic regulation of cardiac homeostasis and heart failure in aging
Ichiro Manabe (Chiba University, Chiba, Japan)

The clinical characteristics of Asian patients with classical-type Hutchinson-Gilford progeria syndrome
Kenji Ihara (Oita University, Oita, Japan)

Special Lecture:
Programs and Progress towards Treatments and The Cure For Children with Progeria
Leslie B. Gordon (Brown University, Providence, USA)

Photo Session

Dinner at Takaraya
(The website is only in Japanese, but you can see the photo of cuisine and interior of Takaraya)

Takaraya located in Kisarazu, Chiba was established in 1897.
Thereafter they have been serving the local taste of Kisarazu for more than 100 years with main menu of Edo-style seafood including popular a short-necked clam dish. They always provide the ingredients that are carefully selected in Kisarazu including the vegetables which they harvested near Boso peninsula.

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Patients and Families Meeting (in Japanese)
Chairs:Kazuki Kobayashi (Asahi General Hospital, Chiba, Japan)
Kinue Kuzuta (Chiba University, Chiba, Japan)

From Patient group of Werner, Cockayne, Rothmund-Thomson syndromes,
Researchers and Doctors

Problem Oriented Sessions for Patients (in Japanese)
Chair:Kazuki Kobayashi (Asahi General Hospital, Chiba, Japan)

Diabetes mellitus and metabolic syndrome
Yoshiro Maezawa (Chiba University, Chiba, Japan)

Skin ulcer and its prevention
Seiichiro Motegi (Gunma University, Maebashi, Japan)

Good shoes for your health

Morning Seminar (Sponsored by MSD K.K.)
Chair: Yoichi Nabeshima (Foundation for Biomedical Research and Innovation, Kobe, Japan)

Roles and mechanisms of cellular senescence in aging and cancer
Eiji Hara (Osaka University, Cancer Institute, Osaka and Tokyo, Japan)

Plenary Lecture 4
Chair: Katsuo Sugita (Chiba University, Chiba, Japan)

Genome maintenance protects from aging and cancer: the impact of nutrition
Jan H. J. Hoeijmakers (Erasumus University, Rotterdam, Netherland)?

Session 6 Xeroderma Pigmentosa and Cockayne syndrome
Chairs:Chikako Nishigori (Kobe University, Kobe, Japan)

Coordinated DNA damage recognition by xeroderma pigmentosum gene products
Kaoru Sugasawa (Kobe University, Kobe, Japan)

The present status of Xeroderma pigmentosum in Japan-evaluation of symptoms by severity scale score

Very mild Japanese Cockayne syndrome (type-IV) cases with a N-terminal truncation mutation in the ERCC6 / CSB gene
Tomoo Ogi (Nagoya University, Nagoya, Japan)

Session 7 Can iPS cells be Future Therapeutics
Chairs:Koji Eto
(Center for iPS Cell Research and Application, Kyoto and Chiba University, Chiba, Japan)
Guanghui Liu (Institute of Biophysics, Chinese Academy of Science, Beijing, China)

Using stem cell and gene editing techniques to study and treat aging-associated disorders

In vitro modeling of bilateral progressive hearing loss with human iPSC technology:
Cellular pathology and drug discovery

Patient-specific iPS cells for neural disease modeling and drug screening
Wado Akamatsu (Juntendo University, Tokyo, Japan)

Closing Remarks
Koutaro Yokote (Chiba University, Chiba, Japan)