Helicase-assisted continuous editing is an emerging genome-engineering strategy that leverages the strand-separating activity of helicases to enable sustained, programmable mutagenesis directly within endogenous genomic loci. By coupling targeted helicase activity with engineered deaminases or other base-modifying enzymes, this approach maintains a locally unwound DNA region long enough to support iterative rounds of editing without requiring double-strand breaks or repeated Cas-induced targeting. The result is a controlled mutational environment capable of generating diverse allelic variants in situ, accelerating the evolution of genes, regulatory elements, and cellular phenotypes. This continuous editing framework offers a powerful alternative to traditional CRISPR-based systems, with reduced genotoxicity and improved compatibility for long-term studies in mammalian cells. As the technology matures, its applications are expanding toward protein engineering, adaptive trait discovery, and functional genomics in both research and therapeutic contexts.